
个人概况
姓名:李亚楠
职称:讲师
学位:理学博士
专业:生物化学与分子生物学
办公室:生科楼417
联系方式:yananli1997@163.com
教育经历
2015.09–2019.07 伟德bv1946官网 学士
2019.09–2025.01 上海科技大学 博士
工作经历
2025.01-至今 伟德bv1946官网 讲师
研究领域
1. 单分子技术解析核酸代谢的分子机制
2. 核酸代谢在褐飞虱与水稻互作中的功能机制
获奖及荣誉
1.第一届全国大学生生命科学竞赛一等奖
2.第四届全国现代生物物理方法与技术暨2023东亚单分子生物学学术研讨会优秀墙报奖
3.上海市优秀毕业生
论文发表
第一作者&通讯(含共同)
1. Jing, S.#*, Xu, J.#, Zheng, F., Jin, J., Huang, X., Mao, L., Wang, F., Zhang, H., Xu, J., Yang, J., Chen, R., Yu, B., Liu, Q.*, and Li, Y.* (2025) NlAgo3 and NlBiwi are essential for piRNAs biogenesis and female reproduction in Nilaparvata lugens. Insect Biochem Mol Biol, 182, 104346.
2. Li, Y.#, Liu, C.#, Jia, X., Bi, L., Ren, Z., Zhao, Y., Zhang, X., Guo, L., Bao, Y., Liu, C., Li, W.* and Sun, B.* (2024) RPA transforms RNase H1 to a bidirectional exoribonuclease for processive RNA-DNA hybrid cleavage. Nat Commun, 15, 7464.
3. Jia, X.#, Li, Y.#, Wang, T., Bi, L., Guo, L., Chen, Z., Zhang, X., Ye, S., Chen, J., Yang, B. and Sun, B.* (2023) Discrete RNA-DNA hybrid cleavage by the EXD2 exonuclease pinpoints two rate-limiting steps. EMBO J, 42, e111703.
4. Liu, C.#, Wang, L.#, Li, Y.#, Guo, M., Hu, J., Wang, T., Li, M., Yang, Z., Lin, R., Xu, W., Chen, Y.H., Luo, M.C., Gao, F., Chen, J.Y., Sun, Q.W., Liu, H.B., Sun, B.*, and Li, W.* (2023) RNase H1 facilitates recombinase recruitment by degrading DNA-RNA hybrids during meiosis. Nucleic acids res, 51, 7357-7375.
参与作者
1. Li, X., Bi, L., Zhang, S., Xu, Q., Xia, W., Tao, Y., Wu, S., Li, Y., Le, W., Kang, W. et al. (2025) Single-Molecule Insight Into alpha-Synuclein Fibril Structure and Mechanics Modulated by Chemical Compounds. Adv Sci (Weinh), e2416721.
2. Song, X., Chen, Z., Sun, W., Yang, H., Guo, L., Zhao, Y., Li, Y., Ren, Z., Shi, J., Liu, C. et al. (2024) CRISPR-AsCas12f1 couples out-of-protospacer DNA unwinding with exonuclease activity in the sequential target cleavage. Nucleic acids res, 52, 14030-14042.
3. Zhao, Y., Guo, L., Hu, J., Ren, Z., Li, Y., Hu, M., Zhang, X., Bi, L., Li, D., Ma, H. et al. (2024) Phase-separated ParB enforces diverse DNA compaction modes and stabilizes the parS-centered partition complex. Nucleic acids res, 52, 8385-8398.
4. Wang, T., Hu, J., Li, Y., Bi, L., Guo, L., Jia, X., Zhang, X., Li, D., Hou, X.M., Modesti, M. et al. (2022) Bloom Syndrome Helicase Compresses Single-Stranded DNA into Phase-Separated Condensates. Angew Chem Int Ed Engl, 61, e202209463.
5. Bi, L., Qin, Z., Wang, T., Li, Y., Jia, X., Zhang, X., Hou, X.M., Modesti, M., Xi, X.G. and Sun, B. (2022) The convergence of head-on DNA unwinding forks induces helicase oligomerization and activity transition. Proc Natl Acad Sci U S A, 119, e2116462119.
科研活动
1.2025年受邀参加第七届全国核糖核酸(RNA)青年学术会议,并作专题报告